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Intra-arterial injection at this location resulted in direct administration of the oil-based formulation into the arterial blood supply of the brain resulting in embolism and death.Since intra-arterial injection was confirmed in three animals that died following injection of EXCEDE Sterile Suspension, the consequences of purposeful intra-arterial injection of EXCEDE Sterile Suspension were investigated in feeder cattle.
Cattle were clinically evaluated on Days 2 to 4, 14 and 28 and were observed on all other study days.
Ceftiofur residues in tissues were less than the tolerances for ceftiofur residues in the kidney by 13 days after the second dose. The needle will be inserted into the loose skin in the posterior aspect of the ear where it attaches to the head (base of the ear) while pointing ventrally. At 13 days post-injection, gross lesions were found in the inedible portions of the base of the ear in all 18 animals, and in the exposed carcass tissue in 11 of 18 animals.The ventral base of the ear injection technique was evaluated in a conditions of use study in 200 beef cattle. The product information provided in this site is intended only for residents of the United States. Repeat this dose in the opposite ear 72 hours after the initial dose. Available for Android and iOS devices. Normal restraint was adequate for 95.5% of animals in the study. None of the 1927 animals treated with EXCEDE Sterile Suspension were removed from this trial due to ear irritation although swelling was noted at some injection sites. These data collectively support that no milk discard period is required for this product.A pivotal tissue residue decline study was conducted in dairy cattle. It is a broad-spectrum cephalosporin antibiotic active against Gram-positive and Gram-negative bacteria including B-lactamase-producing strains treat metritis. Each ml of Excede Sterile Suspension contains ceftiofur crystalline free acid equivalent to 200 mg ceftiofur. Cows with a non-fetid discharge, and a rectal temperature < 103 °F, and that did not require alternate (“escape”) therapy during the 14-day observation period were classified as a cure. ** The lowest MIC to encompass 50% and 90% of the most susceptible isolates, respectively.Based on pharmacokinetic and clinical effectiveness studies of ceftiofur in cattle after a single administration of 3.0 mg CE/lb (6.6 mg CE/kg) BW and the MIC and susceptibility data, the following breakpoints are recommended for BRD pathogens by CLSI.
Intra-arterial injection of EXCEDE Sterile Suspension is likely to result in sudden death of the animal.