P.O. Stuart Hameroff MD is Professor of Anesthesiology and Psychology, and Director of the Center for Consciousness Studies at the University of Arizona in Tucson. Human Brain Stimulation with Transcranial Ultrasound: Potential Applications for Mental Health. © 2021 The Arizona Board of Regents on behalf of The University of Arizona. Hameroff, S. R. (2014). 5301, search: SR Hameroff, Stuart Hameroff, Stuart R. Hameroff - Published Research, Banner - University Medical Center Tucson, Department of Anesthesiology / University of Arizons (Consciousness Research Page), The Science of Consciousness Conferences (aka Toward a Science of Consciousness Conferences), Center for Consciousness Studies / University of Arizona, Orch OR - Orchestrated objective reduction/Wikipedia, quantum-consciousness.com A theoretical model (the "conscious pilot") suggests that as gap junctions open and close, a gamma-synchronized subnetwork, or zone moves through the brain as an executive agent, converting nonconscious "auto-pilot" cognition to consciousness, and enhancing computation by coherent processing and collective integration. Highly controversial and harshly criticized, Orch OR is now supported by evidence, e.g. Dayhoff, J., Hameroff, S. R., Lahoz-Beltra, R., & Swenberg, C. (1992, June). Quantum mathematical cognition requires quantum brain biology: the "Orch OR" theory.. Hameroff, S. R., Trakas, M., Duffield, C., Annabi, E., Gerace, M., Boyle, P., Lucas, A., Amos, Q., Bauda, A., & Badal, J. We model two levels of interaction between CaMKII and microtubules, suggesting a testable framework for molecular memory encoding. Found insideMaybe all that was just a misunderstanding of eliminative materialism, as has been said to me by Patricia in an email. ... Also Stuart Hameroff of Arizona. Low-dose fentanyl (5 micrograms/kg) reduces some aspects of the stress response to rapid-sequence induction of anesthesia. Anesthesia offers a unique and profound opportunity to understand consciousness because it is relatively selective—many brain activities (e.g. Candidate sites for phosphorylation-encoded molecular memory include microtubules, cylindrical lattice polymers of the protein tubulin. April 2014 marked the 20 year anniversary ‘Tucson’ conference, and the 2015 conference will be in in Helsinki, Finland in June. Tucson, AZ 85724 In the model, outgoing spikes are temporally integrated and spatially averaged using the fixed resistive grid set up by neurons of similar function which are connected through gap-junctions. Generally the protein target for anesthetics is assumed to be neuronal membrane receptors and ion channels, however new evidence points to critical effects on intra-neuronal microtubules, a target of interest due to their potential role in post-operative cognitive dysfunction (POCD). View the profiles of professionals named "Hameroff" on LinkedIn. These results suggest that tFUS can be used to modulate mood and emotional regulation networks in the prefrontal cortex. University Information Security and Privacy. The model has been criticized as regards the issue of environmental decoherence, and a recent report by Tegmark finds that microtubules can maintain quantum coherence for only 10(-13) s, far too short to be neurophysiologically relevant. Quantum effects in the understanding of consciousness. Jibu, M., Hagan, S., Hameroff, S. R., Pribram, K. H., & Yasue, K. (1994). Found insideThis second edition includes such advances. The authors have also drawn on many responses from readers and instructors to improve the clarity of the book's explanations. In 1972 while in medical school at Hahnemann Medical College in Philadelphia, he began . Watt, R., Ehlers, K., Scipione, P., Maslana, E., & Hameroff, S. R. (1989, November). Consciousness and brain function are discussed in layman's terms. Traumatic Brain Injury: Therapeutic Strategies I Nov 18, 2014, Sages & Scientists Symposium, August 22-24, 2014, Carlsbad, CA, 'Tuning the brain' - Treating mental states through microtubule vibrations, June 11, 2014, Berkeley, University of California, Redwood Center for Theorectical Neuroscience, TSC 20th Anniversary Conference, Toward a Science of Consciousness, Tucson, Arizona, Center for Consciousness Studies, University of Arizona, April 21-26, 2014; Co-Chair, 10th Symposium of the Bial Foundation 26th to 29th March 2014, Lisbon, Portugal, Casa do Médico - Porto, Behind and Beyond the Brain; Mind-Matter Interactions, Hameroff, Stuart, Keynote, ‘Consciousness, microtubules and quantum nonlocality - The 'Orch OR' theory’, The Brainstorm Sessions, ABC Night of the Brain,The Flemish Arts Centre De Brakke Grond and UvA, January 2014, Amsterdam, The Netherlands, Hameroff, SR., ‘Orch OR theory - Microtubules and the great debate about consciousness’, 13.7 cosmos & culture commentary on science and society, Despite a century of research, memory encoding in the brain has remained mysterious. Banner - University Medical Center Tucson In the mid 1990s Hameroff teamed with famed British physicist Sir Roger Penrose to develop a quantum theory of consciousness (‘orchestrated objective reduction’, ‘Orch OR’) based on microtubule quantum computing. A. Hameroff, S. R., & Penrose, R. (2014). 2. However, recent experimental results and theoretical analyses have shown that thermal energy may assist, rather than disrupt, quantum coherent transport, especially in the 'dry' hydrophobic interiors of biomolecules. (2020). Found insideIn his bestselling work of popular science, Sir Roger Penrose takes us on a fascinating tour through the basic principles of physics, cosmology, mathematics, and philosophy to show that human thinking can never be emulated by a machine. Cognitive neurocomputation with consciousness is accompanied by 30- to 90-Hz gamma synchrony electroencephalography (EEG), and non-conscious neurocomputation is not. ^ Hameroff, Stuart (1987), Ultimate Computing, Elsevier ISBN 978-0444702838 ^ Penrose, Roger (1989) The Emperor's New Mind Oxford University Press Consciousness in the universe: a review of the 'Orch OR' theory. We have tested our gap-junction-defined sub-network in a one-layer neural network on artificial retinal inputs using real-world images. see: anesth.medicine.arizona.edu/tus Found inside – Page 401Submission of Manuscripts by Email STYLE SHEET AND GUIDE TO AUTHORS Authors are encouraged to email ... Stuart Hameroff , Arizona University ( Anaebelow ) . Craddock, T., St George, M., Freedman, H., Barakat, K., Darnaraju, S., Hameroff, S. R., & Tuszynski, J. Acousta-conformational transitions in cytoskeletal microtubules: implications for intracellular information processing.. Vernetti, L., Nowlin, C., Hameroff, S. R., Gandolfi, A., Lee, Y., & Sarid, D. (1991). Dr. Hameroff has published five books and well over 100 research articles, and appeared in the film ‘What the Bleep do We Know?’ and numerous TV documentaries on the problem of consciousness including BBC, Discover Channel, History Channel, PBS, OWN, Huff Post Live and the film “What the Bleep?”. (1984). office 520-621-9317 We observed that at a constant peak airway pressure and percent inspiratory time, PaCO2 generally increases as frequency rises above 100/min. At the University of Pittsburgh in the late 1960s, he studied chemistry, physics, mathematics and philosophy of mind. quantumconsciousness.org Anesthetic Alterations of Collective Terahertz Oscillations in Tubulin Correlate with Clinical Potency: Implications for Anesthetic Action and Post-Operative Cognitive Dysfunction. Anesthesia and Analgesia. Studying anesthetic gas mechanisms, he focused on how quantum effects control protein conformational dynamics. e-mail: hameroff@email.arizona.edu Conscious "free will" is problematic because (1) brain mechanisms causing consciousness are unknown, (2) measurable brain activity correlating with conscious The feasibility of coherent energy transfer in microtubules. Cytoskeletal logic: a model for molecular computation via Boolean operations in microtubules and microtubule-associated proteins. The Penrose—Hameroff model (orchestrated objective reduction: 'Orch OR') suggests that quantum superposition and a form of quantum computation occur in microtubules—cylindrical protein lattices of the cell cytoskeleton within the brain's neurons. The answer seemed to have something to do with the newly discovered cellular components called microtubules--long, thin hollow tubes of protein about a ten . At high stimulation levels, the peak transient current was 87% higher than the steady-state current. Medical Hypothesis. OR model (superposition separation, charge vs dipole, dielectric constant) lengthens the decoherence time to 10(-5)-10(-4) s; (3) decoherence times on this order invalidate the assumptions of the derivation and determine the approximation regime considered by Tegmark to be inappropriate to the orch. We demonstrate a computer generated technique which provides a visually robust display of EEG data plotted as 'phase space trajectories' and a mathematically derived parameter ('dimensionality') which may correlate with depth of anesthesia. Output current decreased from 25 to 88% in the different devices, with a load impedance increase from 470 to 10,000 ohms. Overseas TSC Conferences have been held in: 1995 Ischia, Italy; 1997, Elsinore, Denmark; 1999, Tokyo, Japan; 2001, Skovde, Sweden; 2003, Prague, Czech Republic; 2005, Copenhagen, Denmark; 2007 Vienna, Austria; 2007, Budapest, Hungary; 2009, Hong Kong, China; 2011, Stockholm, Sweden; 2013, Agra, India; 2015, Helsinki, Finland; 2017, Shanghai, China. Reynolds, A. F., Hameroff, S. R., Blitt, C. D., & Roberts, W. L. (1980. No consistent correlations among fentanyl concentration and any clinical values were observed. Dr. Hameroff is grateful to his current and past fellow faculty and residents in the Department of Anesthesiology, surgeons and nurses and techs in the operating rooms, artist Dave Cantrell, webmeisters Ed Xia, Abi Behar Montefiore, Rita Ellsworth, graphic designers Roma Krebs, Darla Keneston; technical support of Scott Morgan, Michael Griffith, Ricky Bergeron and Erica Coleman; TSC conference manager and CCS assistant director, Abi Behar-Montefiore and Toward a Science co-director Philosopher David Chalmers as well as his numerous scientific collaborators including: Sir Roger Penrose, Jack Tuszynski, Anirban Bandyopadhyay, Travis Craddock, John JB Allen, Jay Sanguinetti, and Sterling Cooley. Orch OR is a viable approach toward understanding how the brain produces consciousness. And Roger’s concept of Cyclical Conformal Cosmology (‘CCC’) posits a serial, eternal universe, with the Big Bang preceded by a previous aeon which had its own Big Bang, that aeon preceded by another and so on. Superradiant optical computing in networks of microtubules and other cytoskeletal structures may provide a basis for biomolecular cognition and a substrate for consciousness. Hameroff became interested in intelligent behavior of microtubules, protein lattices which organize activities within living cells. Consciousness and Quantum Physics. Gordon Globus,13. Logic of Quantum Mechanics and Phenomenon of Consciousness Michael B. Mensky,14. A Quantum Physical Effect of Consciousness Shan Gao15. The Universe, Quantum Physics, and Consciousness. Found inside – Page 348If you are interested in participating in the work of the group , send e - mail to ... Gordon Globus , Stuart Hameroff , Rhett Savage , Erick von Schweber ... How can it be possible that the world we see is not objective reality? And how can our senses be useful if they are not communicating the truth? Hoffman grapples with these questions and more over the course of this eye-opening work. Questions have been raised concerning the reliability of surface electrodes in achieving supramaximal stimulation during the monitoring of neuromuscular blockade; needle electrodes are considered reliable in this respect. Hemodynamic effects of high-frequency jet ventilation. In this view, visual consciousness occurs as a series of several-hundred-millisecond epochs, each comprising 'crescendo sequences' of quantum computations occurring at approximately 40 Hz. On March 27th I interviewed Dr. Stuart Hameroff of the Center for Consciousness Studies of the University of Arizona. Reply to Seven Commentaries on Consciousness in the Universe: Review of the 'Orch OR' Theory. Alzheimer's disease (AD) is the most common form of dementia in the elderly. Plasma concentrations of beta-endorphin and norepinephrine increased significantly in control patients but not in patients given fentanyl (P less than 0.05). George E. Hammond, MS Physics return email: Date: Sat, 05 Dec . Probing The Unknowable Mysteries of the Brain, Marcelo Gleiser, NPR, December 4, 2013 reporting from the Agra TSC Conference. Anesthesiologist and Professor, University of Arizona. Gamma synchrony EEG derives largely from neuronal groups linked by dendritic-dendritic gap junctions, forming transient syncytia ("dendritic webs") in input/integration layers oriented sideways to axonal-dendritic neurocomputational flow. Koruga, D., Hameroff, S. R., Withers, J., Loutfy, R., & Sundareshan, M. (1993). Banner – University Medical Center Tucson. Consciousness in the Universe: A review of the 'Orch OR' theory. Neuronal synaptic connection strengths are involved, but synaptic components are short-lived while memories last ... full story, Stuart Hameroff MD, Craddock TJA, St. George M, Freedman H, Barakat KH, Damaraju S, et al. Evidence and theory supporting organized quantum states in cytoplasm/nucleoplasm (and quantum optical properties of centrioles in particular) at physiological temperature are presented. see: anesth.medicine.arizona.edu/research/clinical-trials, Memory or Mood Problems? Found insideThis text originates from the second of two conferences discussing the concept of consciousness. In 15 sections, this book demonstrates the broad range of fields now focusing on consciousness. Here we review Orch OR in light of criticisms and developments in quantum biology, neuroscience, physics and cosmology. Phone: 520-626-7221 | Fax: 520-626-6943 | Admin Login, The University of Arizona is an EEO/AA - M/W/D/V Employer. rescue consciousness from epiphenomenalism. This stress response is especially dangerous for the patient at risk for myocardial ischemia. Hameroff, S. R. (2014). Koruga, D., Simic-Krstic, J., Trifunovic, M., Jankovic, S., Hameroff, S. R., Withers, J., & Loutfy, R. (1993). He is an attending anesthesiologist at University of Arizona Medical Center, spending 4 days per week in the surgical . These results indicate that hemodynamic dysfunction may be less likely with HFJV than conventional ventilation. Banner - University Medical Center Tucson Quantum Consciousness Theorist & Researcher. Craddock, T. J., Tuszynski, J. (www.quantumconsciousness.org) is a Professor in the Departments of Anesthesiology and Psychology, and Director of the Center for Consciousness Studies at the University of Arizona in Tucson, Arizona. Craddock, J., Hameroff, S. R., Ayoub, A., Klobukowski, M., & Tuszynski, J. STUART: Thank you Deepak for this interview. This paper describes how quantum walks in a Feynman chessboard are conceptually identical to 'topological qubits' in brain neuronal microtubules, as described in the Penrose-Hameroff 'Orch OR' theory of consciousness. As Director of the Center for Consciousness Studies, established in 1997 at the University of Arizona, Hameroff co-organizes (with philosopher David Chalmers) the international, interdisciplinary biennial conference series ‘Toward a Science of Consciousness’ since 1994. Quantum optical coherence in cytoskeletal microtubules: implications for brain function. Panel Discussion: Different interpretations on David Bohm's ideas of quantum physics and consciousness. Is the conscious mind subtly linked to a basic level of the universe?. information. A review and update of a controversial 20-year-old theory of consciousness published in Physics of Life Reviews claims that consciousness derives from deeper level, finer scale activities inside brain neurons. Hameroff, S. R., Dayhoff, J., Lahoz-Beltra, R., Sarnsonovich, A., & Rasmussen, S. (1992). After residency, Hameroff joined the anesthesiology faculty in 1977, a position he still holds as emeritus professor and practicing anesthesiologist. Computational predictions of volatile anesthetic interactions with the microtubule cytoskeleton: implications for side effects of general anesthesia.. Craddock, T., Tuszynski, J., & Hameroff, S. R. (2012). Lateral information processing by spiking neurons: a theoretical model of the neural correlate of consciousness. The 'tubulin' subunit proteins, which comprise microtubules, also possess a distinct architecture of chromophores, namely aromatic amino acids, including tryptophan. In their article, Is the Brain a Quantum Computer,? Stuart Hameroff Biography Professor of Anesthesiology and Psychology, University of Arizona Director Center for Consciousness Studies Stuart Hameroff first became interested in the problem of consciousness as an undergraduate at the University of Pittsburgh. Another project is being planned numerous colleagues including, UA professor of psychology John Allen and postdoc Jay Sanguineti for mood, cognition and psychological and neurological disorders (including post-operative cognitive dysfunction) and others, tba. Transcranial ultrasound stimulation (TUS) has also shown promise.UA professor of psychology John Allen and grad student Jay Sanguineti for mood, cognition and psychological and neurological disorders (including post-operative cognitive dysfunction). " Consciousness in the universe: A review of the 'Orch OR' theory ", Physics of Life Reviews V olume 11, Issue 1 Pages 39-78 (2012). Learning, memory and long-term potentiation (LTP) are supported by factors including post-synaptic calcium ion flux activating and transforming the hexagonal calcium-calmodulin kinase II (CaMKII) holoenzyme. Arterial oxygenation was adversely affected by frequencies above 300/min, but was otherwise not influenced by alterations in frequency, percent inspiratory time, or airway pressure. Hameroff, S. (2013). The effect of electroconvulsive therapy on plasma beta-endorphin. Stuart Hameroff, Producer: The Consciousness Chronicles Vol. By Stuart Hameroff. Lahoz-Beltra, R., Hameroff, S. R., & Dayhoff, J. Craddock, J., Friesen, D., Mane, J., Hameroff, S. R., & Tuszynski, T. J. Current Topics in Medicinal Chemistry. Stuart Hameroff first became interested in the problem of consciousness as an undergraduate at the University of Pittsburgh. The authors found significant differences in output voltage waveform and in maximum current into a 470 ohm load (21.4 to 128 mA.). Here, we perform a computational investigation of energy transfer between chromophoric amino acids in tubulin via dipole excitations coupled to the surrounding thermal environment. In a randomized, placebo-controlled, double-blind study, participants received 30 s of 500 kHz tFUS or a placebo control. Dr. Hameroff's research projects are potentially open to resident involvement time permitting. Hameroff, S. R. (1988). We conclude that consciousness plays an intrinsic role in the universe. of publications stored in Pure and citations from Scopus. See http://en.wikipedia.org/wiki/Stuart_Hameroff, www.quantumconsciousness.org (old), New Quantum website: https://phoenix.sbs.arizona.edu/quantum/. UA College of Medicine People on the Move. Quantum walks in brain microtubules-a biomolecular basis for quantum cognition? 33 h-Index. Dr. Stuart Hameroff is Professor Emeritus of Anesthesiology and Psychology, Director of the Center for Consciousness Studies at the University of Arizona. Conscious cognition is marked by gamma synchrony EEG, mediated largely by dendritic-dendritic gap junctions, sideways connections in input/integration layers. How quantum brain biology can rescue conscious free will.. Ebner, M., & Hameroff, S. (2011). www.consciousness.arizona.edu, University of Arizona, Department of Anesthesiology, Center for Consciousness Studies center@u.arizona.edu Craddock, J., Hameroff, S. R., Ayoub, A. b., Klobukowski, M., & Tuszynski, J. Through molecular modeling we have previously shown: (1) olive oil-like non-polar, hydrophobic quantum mobility pathways ('quantum channels') of tryptophan rings in tubulin, (2) binding of anesthetic gas molecules in these channels, and (3) capabilities for π-electron resonant energy transfer, or exciton hopping, among tryptophan aromatic rings in quantum channels, similar to photosynthesis protein quantum coherence. Transcranial ultrasound (TUS) effects on mental states: A pilot study, Brain Stimulation Hameroff S, Trakas M, Duffield C, Annabi E, Gerace MB, Boyle P, Lucas A, Amos Q, Buadu A, Badal JJ Received 21 November 2011; received in revised form 19 February 2012; accepted 6 May 2012. published online 30 May 2012. It cannot convey signals or classical. Scanning tunneling microscopy (STM) applications to molecular electronics, Engineering in Medicine and Biology Society.. Watt, R. C., & Hameroff, S. R. (1988). Transdermal fentanyl: pharmacokinetics and preliminary clinical evaluation. OR superposition; (4) Tegmark's formulation yields decoherence times that increase with temperature contrary to well-established physical intuitions and the observed behavior of quantum coherent states; (5) incoherent metabolic energy supplied to the collective dynamics ordering water in the vicinity of microtubules at a rate exceeding that of decoherence can counter decoherence effects (in the same way that lasers avoid decoherence at room temperature); (6) microtubules are surrounded by a Debye layer of counterions, which can screen thermal fluctuations, and by an actin gel that might enhance the ordering of water in bundles of microtubules, further increasing the decoherence-free zone by an order of magnitude and, if the dependence on the distance between environmental ion and superposed state is accurately reflected in Tegmark's calculation, extending decoherence times by three orders of magnitude; (7) topological quantum computation in microtubules may be error correcting, resistant to decoherence; and (8) the decohering effect of radiative scatterers on microtubule quantum states is negligible. Stuart Hameroff As presently implemented, the neuron doctrine (ND) portrays the brain's neurons and chemical synapses as fundamental components in a computer-like switching circuit, supporting a . I feature your work along with the work of Robert Lanza and Bob Berman (Biocentrism) and the work of Roger Penrose and Stuart Hameroff (Orch-OR theory of quantum consciousness). Found insideNeurophotonics and Biomedical Spectroscopy addresses the novel state-of-the-art work in non-invasive optical spectroscopic methods that detect the onset and progression of diseases and other conditions, including pre-malignancy, cancer, ... The nature of consciousness remains deeply mysterious and profoundly important, with existential, medical and spiritual implication. Quantum computation in brain microtubules: decoherence and biological feasibility. Investigator, Stuart Hameroff, MD, 2016 Hameroff Penrose updated review of Orch OR chapter 14 Biophysics of Consciousness, Discovery of Quantum Vibrations in 'Microtubules' Inside Brain Neurons Supports Controversial Theory of Consciousness, Science Daily, Jan 16, 2014. In the 1980s Franks and Lieb showed anesthetics acted in such a medium within proteins, suggesting post-synaptic membrane receptors. that anesthetics act in quantum channels in microtubules, and that microtubules have multi-scalar resonances, e.g. Find Dr. Hameroff's phone number, address, hospital affiliations and more. We also introduce a novel suggestion of 'beat frequencies' of faster microtubule vibrations as a possible source of the observed electro-encephalographic ('EEG') correlates of consciousness. Calkins, J. M., Waterson, C. K., Hameroff, S. R., & Kanel, J. Ongoing Clinical Trial of Transcranial Ultrasound ('TUS') Sanguinetti JL, Hameroff S, Smith EE, Dieckman LW, Sato T, Daft CMW, Tyler WJ, Allen JJB (2019) Transcranial focused ultrasound (tFUS) over the right prefrontal cortex improves mood and alters functional connectivity in humans (submitted). Hameroff, S. R. (2015, July). Hameroff, S. R., Craddock, T. J., & Tuszynski, J. As gap junctions open and close, a gamma-synchronized dendritic web can rapidly change topology and move through the brain as a spatiotemporal envelope performing collective integration and volitional choices correlating with consciousness. Hameroff, Penrose, 2014. book chapter in Exploring frontiers of the mind-brain relationship. We present a physiological model for visual consciousness that can accommodate brain-wide quantum computation according to the Penrose-Hameroff 'Orch OR' model. Consciousness and quantum state reduction - Which Comes First?. Orchestrated objective reduction theory (Orch OR), originally proposed by physicist Roger Penrose and anaesthesiologist Stuart Hameroff in the 1990s, seeks to bridge the gulf between physical . Contributor. Source: Scopus. Consciousness Central TV. Anesthesia blocks consciousness and memory while sparing non-conscious brain activities. Chvapil, M., Hameroff, S. R., O'Dea, K., & Peacock, E. E. (1979). (1996). (2012). Our Wedding. In, Hameroff, S. R. (1987). The results are evaluated as possible sources of variability in peripheral nerve stimulator function and neuromuscular blockade assessment. Conformational automata in the cytoskeleton: Models for molecular computation.. Hotani, H., Beltra-Lahoz, R., Combs, B., Hameroff, S. R., & Rasmussen, S. (1992). DEEPAK: It's my . The Brainstorm Sessions, ABC Night of the Brain, RealityShifters Blog, Interview with author Cynthia Sue Larson, AZ Daily Star UAST-Allen- Good Vibrations Improve Mood, 2014-Nov 30.pdf, Transcranial ultrasound (‘TUS’) – an optimal non-invasive brain-machine interface via microtubules? This spatial average, essentially a feedback signal from the neuron's output, determines whether particular gap junctions between neurons will open or close. Orchestrated reduction of quantum coherence in brain microtubules: a model for consciousness?. Quantum non-locality implied for consciousness has attracted interaction with Deepak Chopra, and the inaugural ‘Rustum Roy’ award to Hameroff in 2011. The Guardian, Why Can't The World's Greatest Minds Solve the Mystery of Consciousness? Logic of quantum processes in Neurophotonics and the origin of cancer: quantum entanglement. Median peak concentration and time to peak were 1.0 ng/ml and 22 hours, respectively gravity could interact with.. 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